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KMID : 1134820190480101172
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 10 p.1172 ~ p.1177
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Protective Effect of Jujube Water Extract against UVB-Induced Skin Photoaging in Human Skin Fibroblasts
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Hong Seong-Hwa
Lee Ha-Na
Jeong Taek-Young
Kim Young-Hwa
Jeong Heon-Sang
Lee Jun-Soo
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Abstract
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Skin is damaged by intrinsic and extrinsic factors, such as aging, ultraviolet (UV) light, and pollutants. UV irradiation induces the synthesis of matrix metalloproteinases (MMPs) and collagen degradation, which in turn causes skin photoaging and photocarcinogenesis. This study examined the anti-photoaging activity of jujube water extract (JWE) against UVB-induced damage in human fibroblast (Hs68 cells). The JWE did not show any cytotoxicity up to 50 μg/mL. Treatment with JWE prevented UVB-induced cytotoxicity in Hs68 cells. The protective effect of JWE appeared to be mediated by inhibiting intracellular reactive oxygen species by 21, 25, and 27% at a concentration of 12.5, 25.0, and 50.0 μg/mL, respectively. UVB increased the production of MMP-1/3 and decreased collagen synthesis. On the other hand, treatment of JWE attenuated the UVB-induced production of MMP-1/3 and prevented the reduction of collagen. These results suggest that JWE has a considerable inhibitory effect on the photoaging induced by UVB irradiation. This study showed that JWE could be used as a photo protective agent in cosmetic products.
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KEYWORD
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jujube, photoaging, collagen, fibroblast
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